A continuum model of docking of synaptic vesicle to plasma membrane.

نویسندگان

  • Tianshu Liu
  • Pankaj Singh
  • James T Jenkins
  • Anand Jagota
  • Maria Bykhovskaia
  • Chung-Yuen Hui
چکیده

Neurotransmitter release from neuronal terminals is governed by synaptic vesicle fusion. Vesicles filled with transmitters are docked at the neuronal membrane by means of the SNARE machinery. After a series of events leading up to the fusion pore formation, neurotransmitters are released into the synaptic cleft. In this paper, we study the mechanics of the docking process. A continuum model is used to determine the deformation of a spherical vesicle and a plasma membrane, under the influence of SNARE-machinery forces and electrostatic repulsion. Our analysis provides information on the variation of in-plane stress in the membranes, which is known to affect fusion. Also, a simple model is proposed to study hemifusion.

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عنوان ژورنال:
  • Journal of the Royal Society, Interface

دوره 12 102  شماره 

صفحات  -

تاریخ انتشار 2015